03/02/2017 · Infections by Carbapenem-Resistant Enterobacteriaceae CRE, in particular, carbapenem-resistant Klebsiella pneumoniae CRKp, are a significant public health challenge worldwide. Resistance to carbapenems in enterobacteriaceae is linked to different mechanisms, including the production of the. Global Priority List of Antibiotic-Resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics World Health Organization, 2017. Falagas, M. E. et al. Risk factors of carbapenem-resistant Klebsiella pneumoniae infections: a matched case-control study. J. Antimicrob. Chemother. 06/11/2019 · The increasing incidence of carbapenem-resistant Klebsiella pneumoniae CR-KP fundamentally alters the management of patients at risk to be colonized or infected by such microorganisms. Owing to the limitation in efficacy and potential for toxicity of the alternative agents, many experts recommend.
10/12/2013 · Carbapenem-resistant Klebsiella pneumoniae CRKP is resistant to almost all antimicrobial agents, is associated with substantial morbidity and mortality, and poses a serious threat to public health. The ongoing worldwide spread of this pathogen. 25/01/2011 · The aim of this study was to evaluate the impact of carbapenem-resistant K. pneumoniae bloodstream infections on mortality. During the study period 42, 68 and 120 patients were identified with carbapenem-resistant, extended-spectrum b-lactamase producers ESBL and susceptible K. pneumoniae bloodstream infections, respectively. Patients with. 25/06/2019 · We report blaKPC-2–harboring carbapenem-resistant Klebsiella pneumoniae in an emerging sequence type 307 lineage in a traveler returning from Puerto Rico to the Dominican Republic. Phylogenetic analyses indicate regional dissemination of this highly drug-resistant clone across the Americas, underscoring the need for adequate. 23/02/2015 · When Enterobacteriaceae develop resistance to the group of antibiotics called carbapenems, the germs are called carbapenem-resistant Enterobacteriaceae CRE. CRE are difficult to treat because they do not respond to commonly used antibiotics. Occasionally CRE are resistant to all available antibiotics. CRE are a threat to public health.
26/12/2016 · The rapid emergence of carbapenem-resistant Klebsiella pneumoniae CRKP represents a major public health threat, including in the long-term acute care hospital LTACH setting. Our objective in this study was to describe the epidemiologic characteristics of. Carbapenem-resistant Enterobacteriaceae CRE have been defined as carbapenem-nonsusceptible and extended-spectrum cephalosporin-resistant Escherichia coli, Enterobacter aerogenes, Enterobacter cloacae complex, Klebsiella pneumoniae, or Klebsiella oxytoca. Some exclude ertapenem resistance from the definition. Risk factors. 28/03/2017 · Abstract. Klebsiella pneumoniae poses a major challenge to healthcare worldwide as an important cause of multidrug-resistant infections. Nosocomial clones, including epidemic sequence type 258 ST258, have shown an affinity for acquiring and disseminating resistance plasmids, particularly variants of the K. pneumoniae carbapenemase.
25/10/2019 · Carbapenem resistance among Klebsiella pneumoniae has dramatically increased. What is the most effective course of treatment for CR-KP infections? carbapenem-resistant Klebsiella pneumoniae: a Trojan horse In The Lancet Infectious Diseases, Danxia Gu and colleagues1 reported the emergence and evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae CR-HvKP strains, which have caused fatal infections at the Second Affiliated Hospital of Zhejiang University Hangzhou, China. One of many CREs is carbapenem-resistant Klebsiella pneumoniae CRKP. Over the past 10 years, a progressive increase in CRKP has been seen worldwide; however, this new emerging nosocomial pathogen is probably best known for an outbreak in Israel. 28/10/2019 · Figure 2. Potential antibiotic combination therapy algorithm for the treatment of carbapenem-resistant Klebsiella pneumoniae infections. hypervirulent carbapenem-resistant Klebsiella pneumoniae isolates from bacteremia. Genome Announc 2016; 4: e01081–16. 4 Zhang R, Lin D, Chan EW, Gu D, Chen GX, Chen S. Emergence of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae strains in China.
Klebsiella pneumoniae è diventata una infezione nosocomiale in crescita dato che continuano ad apparire ceppi antibiotico-resistenti. Lo scienziato danese Hans Christian Gram 1853–1928 ha sviluppato la tecnica nota come colorazione di Gram nel 1884 per distinguere la Klebsiella pneumoniae dallo Streptococcus pneumoniae. 21/11/2016 · Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae Hesna Yigit, 1 Anne Marie Queenan, 2 Gregory J. Anderson, 1 Antonio Domenech-Sanchez, 3 James W. Biddle, 1 Christine D. Steward, 1 Sebastian Alberti, 4 Karen Bush, 2 and Fred C. Tenover 1,. Carbapenem-resistant Klebsiella pneumoniae. The CDC says that some Klebsiella strains have become resistant to carbapenem antibiotics, meaning these antibiotics won't work to kill the bacteria. Carbapenems are related to penicillin and often the last line of defense when someone has an infection. The emergence of a hypervirulent plasmid in prevalent strains of Klebsiella pneumoniae threatens the effective prevention and treatment of infections caused by this clinically untreatable pathogen, which could become a serious public health problem globally.1 In The Lancet Infectious Diseases, Danxia Gu and colleagues2 reported a fatal outbreak.
Carbapenem-resistant Klebsiella pneumoniae infection causing rupture of graft artery in solid organ recipients. Medicine. 2019;98:45e17878. CY and XH contributed equally to this work. This study is supported by the National Natural Science Foundation of China Grant No. 81702408. Carbapenem resistance was calculated as resistance R to at least one of the following antibiotics: imipenem and meropenem. Since data vary with regard to the representativeness of the underlying population, the CAESAR network assigns levels of evidence to guide the reader in interpreting the presented data, whereas EARS-Net does not make this distinction. 01/01/2018 · In The Lancet Infectious Diseases, Danxia Gu and colleagues1 reported the emergence and evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae CR-HvKP strains, which have caused fatal infections at the Second Affiliated Hospital of Zhejiang University Hangzhou, China. Although little is known about the pathogenesis of CR-HvKP. 30/07/2019 · The prevalence of carbapenem-resistant Klebsiella pneumoniae CRKP is rapidly increasing worldwide in recent decades and poses a challenge for today’s clinical practice. Rapid detection of CRKP can avoid inappropriate antimicrobial therapy and save lives. Traditional detection methods for CRKP are extremely time-consuming; PCR and. 01/08/2019 · On December 31, 2018, Public Health — Seattle & King County PHSKC was notified by the Antibiotic Resistance Laboratory Network regarding a carbapenem-resistant Klebsiella pneumoniae CR-Kp isolate cultured from the urinary tract in a man aged 65 years.
10/12/2016 · Kaplan-Meier curve showing the 30-day in-hospital survival for patients with colistin-resistant carbapenem-resistant Klebsiella pneumoniae CRKp as compared to colistin-susceptible CRKp. Patients were censored at the time of hospital discharge. 25/05/2017 · Introduction Carbapenem-resistant Klebsiella pneumoniae CRKP is of growing concern globally. The risk for transmission of antimicrobial resistant organisms across several continents to the Caribbean is a real one given its tourism industry. After a cluster of cases of CRKP were detected, several studies detailed in this report were. Carbapenem resistance in Enterobacteriaceae such as Klebsiella pneumoniae and Escherichia coli poses a significant threat to patients and healthcare systems in all European Union/European Economic Area EU/EEA countries. Carbapenem-resistant Enterobacteriaceae CRE infections are associated with high mortality, primarily due to delays in.
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